Proheart injection killed my dog – Are ProHeart injections safe?

Zoetis manufactures the popular heartworm preventative injection ProHeart. Dogs are injected with it once a year to prevent heartworm infection. It contains moxidectin as its active ingredient. Many pet owners are concerned that ProHeart injections will kill their dogs.

Dogs should be kept away from ProHeart, a heartworm injection. On behalf of all the dogs who have died from this drug, I am writing this letter. After receiving an injection of ProHeart 12, Katie, six years old, died. The woman never suffered from any health problems before the shot, and was active until the very end.”

On the 20th of January, I took Finn, a golden retriever, to the vet for his yearly checkup. He was fine, the vet said, and he gave him a six-month ProHeart shot to prevent heartworms. According to the vet, the shot was safe and effective. On January 23, my dog died. A veterinarian told me that this drug had been used in the US for years and was safe.

This link includes stories of dogs that have died after receiving this shot (and others who are having serious reactions). If your dog needs heartworm medication, you should be aware of this drug. Many other medications are available; this one is not recommended.

This drug can cause liver failure, seizures, and even death.”. While the manufacturer claims these are rare side effects, other dogs have reported experiencing these problems. When my dog received her shot, I was not made aware of these potentially fatal side effects, and neither were the owners of other dogs who died after receiving this drug.

Also Read: Benadryl killed my dog – Can dogs die from Benadryl?

Moxidectin Poisoning: What is it?

Moxidectin is a drug used to treat parasitic infections in dogs, cats, and large farm animals. This is similar to other anthelmintic drugs such as ivermectin and milbemycin, in that it interferes with crucial neurotransmissions in parasites, causing them to become paralyzed and die. A number of different parasites can be treated with Moxidectin, which is available in oral, topical, and injectable forms.

Dogs and other animals often use it for treating heartworm. The use of moxidectin in dogs is safe in the correct dosage, but side effects can occur. Moxidectin poisoning can result in severe symptoms or even death when taken in high doses that can cross the blood-brain barrier. Ingestion or topical exposure can result in poisoning. 

There are certain breeds of herding dogs that are particularly susceptible to moxidectin poisoning because they are sensitive to avermectin. Even a small dose of drugs can be toxic to these dogs due to a mutation that lets drugs easily cross the blood-brain barrier.

Large doses of parasite medications for horses and other farm animals often cause toxicity in animals that are not sensitive. Symptoms have also been reported in dogs who ingest horse feces immediately after the horses were dewormed. Symptoms of moxidectin poisoning include nausea, vomiting, and excessive salivation. In most cases, treatment is successful.

Dogs and other animals are treated with moxectin to kill parasites. Moxidectin overdose can cause life-threatening neurological symptoms, but it is safe in recommended doses.

A major financial burden can be incurred by treating moxidectin poisoning on your own. The majority of pet insurance companies reimburse claims within 3 days, putting 90% of the bill back in your pocket.

Also Read: Vetoryl Killed My Dog – Can Vetoryl Kill My Dog?

Is ProHeart injection fatal to dogs?

An injection site reaction, gastrointestinal problems, and effects on the central nervous system, such as depression, lethargy, and seizures, may occur with ProHeart. ProHeart injections can cause life-threatening allergic reactions (anaphylaxis) in some dogs. Unless treated promptly with epinephrine (adrenaline), anaphylaxis can lead to death.

Injection site reactions such as abscesses, lumps, or swelling are the most common side effects reported after administering ProHeart injections. Most of these reactions disappear on their own within several days. There have also been reports of vomiting and diarrhea.

Adverse reactions are usually mild and resolve without treatment within 24 hours. Your pet needs to be examined by a veterinarian as soon as possible if serious adverse reactions have occurred.

What Is ProHeart 12?

Heartworm prevention for dogs with this injectable is designed to last for 12 months. Hookworm infections are also treated with this injectable.

Be sure to talk to your veterinarian before thinking “oh, that’s so convenient – I’ll ask him/her about that” … 

Please hold your horses!  A prescription from your veterinarian won’t do any good if you don’t understand it. 

Drugs like ProHeart 6 are stronger versions of this drug. The drug was introduced in 2000 and offers six months of heartworm protection. 

After many reports of adverse reactions (including deaths), it was taken off the market in 2004. 

Heartworm Drugs and Their Risks. The side effects of ProHeart 12 are not known yet, since it is a new product. 

However, it contains moxidectin – the same active ingredient that is found in ProHeart 6 – at a higher dosage. 

Moxidectin Poisoning in Dogs: Diagnosis

Detection of the condition is easiest if there is a history of moxidectin exposure. Both blood and urine samples will be taken by the veterinarian. A serum blood test can be used to confirm Moxidectin poisoning, though this may take some time since the test must be processed by a lab.

Dogs respond to stimuli and symptomatic diagnoses are made based on their reactions. This makes moxidectin poisoning more likely if your dog belongs to a sensitive breed. A dog’s exposure to moxidectin or other similar medications, whether from its own medication or medication intended for other large farm animals, should be considered.

There are veterinary institutions in the United States that offer testing for dogs that may be avermectin sensitive, such as Washington State University. When possible, avoid moxidectin medications in breeds that are known to be sensitive.

What are the side effects of ProHeart?

In addition to nausea, vomiting, lethargy, diarrhea, and changes in liver enzymes, ProHeart can cause anorexia. It may cause an allergic reaction in some dogs. There are a variety of symptoms of a reaction, including swelling of the face, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, and coma.

Consult your veterinarian before giving ProHeart to sick dogs or those who are taking other medications.

Also Read: Vetmedin killed my dog – How To Handle It?

Is heartworm injection necessary?

The procedure of heartworm prevention is relatively new: heartworm injections. Heartworms are protected by an injection every six or twelve months.

A monthly pill or topical treatment isn’t as effective as injections. They aren’t completely effective either. This injection has the main advantage that pet owners need not remember to give their pets a pill or to apply a topical each month.

You should discuss whether the injection is right for your pet with your veterinarian since it does have some possible side effects.

Dogs can die of heartworm disease. Mosquitoes that carry heartworm larvae bite pets, causing them to become infected. The larvae mature into adult worms that live in the heart and lungs after they have been injected into an animal.

As they grow, they can cause damage to organs, such as the lungs and heart, which can lead to death. As a preventive measure, many people opt to use heartworm medication instead of treatment.

How to treat a dog poisoned with moxidectin

Vomiting will be induced if poisoning occurred recently (within 1-4 hours). When the incident occurred within the last 24 to 36 hours, activated charcoal may also be administered. As a result, the medication can reduce the absorption of toxic drugs in the gastrointestinal tract. If the exposure was primarily topical, a dog will first need to be washed with warm water and detergent.

If necessary, the veterinarian will administer IV fluids to restore electrolyte balance. In cases of hypothermia, external heat may be required. Dogs with moxidectin poisoning may not respond well to diazepam.

Diazepam or an anesthetic such as propofol may be prescribed if necessary for seizure treatment. Novel treatments such as lipid injections have also proven effective in reducing neurological symptoms.

The symptoms can last for a week or longer in some cases. The veterinarian may recommend keeping your dog in a veterinarian hospital during this period, or he may discharge him with careful monitoring instructions.

Recovery of Moxidectin Poisoning in Dogs

Moxidectin poisoning usually responds well to treatment, and there is a high likelihood of recovery. However, prompt treatment is essential, as otherwise symptoms can be fatal.

Don’t give your dog any medications unless your veterinarian has prescribed them or it is suggested on the package. If you notice any side effects, call your veterinarian immediately. 

Dogs will be toxic if given these doses of medications when giving them to large farm animals. If your dog has just received worm medication, keep him away from feces. A dog whose breed is known to be sensitive should be given special care when taking any medication containing moxidectin. Consult your veterinarian about the safest medications for your dog if your dog has this condition.

Also Read: Metacam killed my dog – How much Metacam is toxic to dogs?

Moxidectin overdose in dogs is possible?

Moxidectin can be overdosed on by dogs. Mantinectin is used in the treatment of parasitic worms and heartworm disease. Ingestion of large quantities of this can be fatal to dogs.

In addition to vomiting and diarrhea, symptoms of moxidectin toxicity include lethargy, disorientation, and lethargy. These symptoms may appear hours to days after the medication has been consumed.

In dogs suffering from moxidectin toxicity, a veterinarian may administer intravenous fluids and activated charcoal, which removes the medication from the stomach before it can be absorbed by the intestinal wall.

Is ProHeart injection safe?

Protecting your dog against heartworm disease with ProHeart is safe and effective. ProHeart is the only injectable heartworm preventatives available for long-term use. With ProHeart, monthly dosing is eliminated and continuous protection is provided.

ProHeart 6 prevents heartworm disease in dogs older than six months with an injection. Dogs 12 months of age and older may receive ProHeart 12 every 12 months.

What are the first signs of heartworms in dogs?

Initial symptoms of heartworm disease are generally non-specific and can mimic those of other diseases. There may be coughing, decreased appetite and stamina, or depression in your dog. Heartworm infection may not show any symptoms at all in some dogs. A veterinarian should perform an annual physical exam and heartworm test to check for these worms since these early symptoms can be easily missed or confused with other health concerns.

Symptoms such as labored breathing, fainting spells, or sudden death may occur as the disease progresses. As soon as you get your puppy, you should start him on preventative medication and perform regular tests. Heartworms can lead to severe lung infection, heart failure, and even death in dogs if left untreated.

What Are Heartworm Shots?

Heartworm shots are administered just twice a year, unlike oral or topical medications that need to be taken monthly. The only FDA-approved heartworm vaccine, ProHeart 6 (Moxidectin), protects for six months. Hookworm infections can also be treated.

Using microspheres, ProHeart 6 prolongs the effectiveness of the active ingredient moxidectin. An absorbable lipid makes up microspheres, which are small, solid spheres. These spheres contain moxidectin, the active ingredient.

These spheres start to dissolve as soon as the medication is injected, slowly releasing moxidectin into the dog’s system. Parasites are paralyzed and killed by carboxylectin, a neurotoxin.

Veterinarians can only administer ProHeart 6 to ensure proper dosing. A subcutaneous injection is given either on the left or right side of a dog’s neck at the base.

Also Read: Doxycycline killed my dog – Can doxycycline harm a dog?

Why was ProHeart taken off the market?

There were many adverse reactions cited by the FDA, including several patient deaths (which is a bad thing, I admit). It’s funny (funny-strange, not funny-haha) that the product continues to be used around the world with no problems from what we can tell.

Is ProHeart 12 safe for dogs?

Ivermectin is a common ingredient in oral heartworm preventatives and has also been found to be safe for dogs sensitive to it. Consult your veterinarian about whether or not your dog would be a good candidate.

Can a heartworm shot make my dog sick?

Prior to administering the drug, a dog must also be healthy, have a blood organ function test, and have a negative heartworm test. Vomiting and diarrhea are common side effects.

What is the safest heartworm medicine for dogs?

Ivermectin (used in Heartgard by Merial, and other products) and milbemycin oxime (used in Interceptor by Novartis) are the most common (and generally considered safe) heartworm preventative ingredients used today.

Is ProHeart better than Heartgard?

In both studies, ProHeart 12 was significantly more effective than Heartgard Plus or Interceptor Plus in preventing the development of heartworms resistant to ML.

Does ProHeart injection have side effects?

Symptoms of ProHeart 6 include swelling of the face, itching, hives and/or inflamed skin. There have been reports of allergic reactions when ProHeart 6 and vaccines have been given together. These reactions can be severe, resulting in breathing difficulties or even collapse.

Also Read: Baytril killed my dog – Is Baytril toxic to dogs?

Reviews that are positive

Reviewers of ProHeart Injections say the injections’ effectiveness against heartworm disease is worth the side effects. It has been observed that pets who have problems after getting ProHeart to find relief by taking an antihistamine or another medication.

A 6-month injection and a 12-month injection are available for the product. Injections lasting 12 months are more expensive but last longer than the others.

Among heartworm preventatives, ProHeart Injection receives some of the best ratings. Users typically report that it did not cause any side effects in their dogs. Those who did encounter problems report that their dogs’ symptoms disappeared within 24 hours of using the product, and they would repurchase it because it is so effective at preventing heartworm infection.

My experience using ProHeart 6 over the years has always been positive. No adverse effects have ever been reported by my patients. The only problem I have is the price of ProHeart 6 which has risen significantly in recent years.”

This product is great!” It is safer, lasts longer, and is much easier to administer than other heartworm treatments. You won’t have to worry about forgetting to give it!

For many years, I have used ProHeart 12 injections and have always found them to be very effective. My dog is usually very nervous when we arrive at the veterinarian’s office, so I knew that he wouldn’t want to get the shot, but I felt comfortable knowing that he would be protected against heartworms for 12 months.

The shots he’s had have never caused a reaction in him, and we’ve never had an issue with him getting heartworms. The vet also highly recommends it.



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